Phytocannabinoids Likely To Interact With Prescription Medication

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Researchers recently published a compilation of drugs that are likely to interact with phytocannabinoid products in the peer-reviewed journal named ‘Medical Cannabis and Cannabinoids’. There are prescription drugs, like contraceptive pills, anticoagulants, and pain relievers, as well as, cannabidiol oil in the list. Somehow, it is related to cannabis’s legality and popularity.

The idea of making cannabis legal is something that caused arguments both in favor of and against the move. The outcomes of a 2013 survey indicated that 52% of grown-ups in the United States supported the idea. Cannabis may be a federally illegal substance even today, but 33 US states have made multiple constituents of the herb legal. Some nations have also legalized medical cannabis.

Besides the more conventional ways of utilizing cannabis, like smoking, cannabidiol oil consumption is becoming increasingly popular. This means more and more people are looking to buy CBD oil online and offline, and some of these products contain tetrahydrocannabinol. For your information, THC is a mind-altering component of the cannabis herb.

There are many purported health benefits of the oil, which include alleviation of pain and anxiety. The sale and use of CBD oil made from industrial hemp are legally allowed everywhere in the US. Recent statistics reveal that the trade of CBD goods in the nation grew to about $850 million last year. More individuals may be using phytocannabinoid goods, but there is not much information about how these can interact with standard forms of medication.

To address this gap in knowledge, researchers at the Pennsylvania State University College of Medicine published the compilation of prescription drugs. The products may not have the intended effect when individuals use these with recreational cannabis, cannabidiol oil, or other medical phytocannabinoid products. The details published in the peer-reviewed journal could aid medical professionals in prescribing phytocannabinoid goods in a safer manner than before. That surely sounds assuring.

Healthcare industry experts always recommend talking to a medical professional before you look to buy cannabis oil or any other derivative of the plant. The reason why it is recommended is that these products are likely to interact with prescription medication.

Drug-Drug Interaction

The proliferation of cannabis derivatives in the market makes it easier to buy products with a variable level of the phytocannabinoids cannabidiol and tetrahydrocannabinol. This particular variation is an important concern for goods that are not regulated, as the university professor, Kent Vrana elucidates. “Unregulated products often contain the same active ingredients as medical cannabinoids, though they may be present in different concentrations.”

Presently, there are very few details about what effects the regulated and unregulated products may have on the functions of usual prescription drugs. So, the clinical pharmacist, Paul Kocis, and his colleague Vrana compiled possible interactions between phytocannabinoids and prescription drugs.

They searched for phytocannabinoid products that could either impact how fast the human body digests prescription drugs or compete for this goal. They evaluated 4 phytocannabinoid products, including the items containing THC namely nabilone, nabiximols, cannabidiol, and dronabinol, plus CBD-only goods.

The researchers viewed a compilation of enzymes that process cannabidiol and tetrahydrocannabinol, and they compared it against prescription medications to discover the interaction. They have listed 57 prescription medications that could affect the medical or recreational use of phytocannabinoids.

The Compilation

The list has many different drugs, which include the following.

  • Anti-depressant drugs like lofepramine, clomipramine, and amitriptyline
  • Oral contraceptives such as ethinylestradiol
  • Thyroid hormones such as levothyroxine
  • Sedatives like propofol
  • Opioid pain medication like fentanyl
  • Blood thinners like warfarin and acenocoumarol

The entire compilation is available on the Penn State University website. The list has drugs with a slim therapeutic ratio, meaning a narrow margin between their toxic dosage and therapeutic dose. This margin creates interactions that may make the utilization of these products more of a concern. The university researchers have published a longer compilation of drugs too, and these products could interact with phytocannabinoids but have a much lower possibility for it. The authors stated that they would update the lists when new drugs are approved and fresh evidence comes.

Cardiac Risk

Dizziness and confusion are two of the likely effects of combining phytocannabinoids with the drugs, but in their study, the authors warn of much more severe problems, which include heart-related issues. They stated that the changes in both heart rhythm and blood pressure might happen if the individuals use phytocannabinoids with drugs that affect the vascular system similarly.

The authors recommended considering an individual’s use of phytocannabinoids when prescribing standard drugs. In addition to this, they also encourage people to be open about their cannabinoid intake. They also noted that the possibility of interaction varies. It largely depends on one’s gender, genetics, age, and health. Therefore, the doctors and medical practitioners also have to think about the four factors mentioned above when they make any medical choice.